iS Clinical Retinol+ Emulsion 0.3™

No. This product contains retinol (a derivative of vitamin A), which is not recommended for use during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or nursing, please discontinue use and consult your doctor or midwife. Consider switching to a retinol-free alternative such as a bakuchiol-based product during this time.

Absolutely. Retinol increases your skin's sensitivity to UV radiation, so applying a broad-spectrum SPF every morning is essential when using this product — even on cloudy days. You should also wear protective clothing and limit direct sun exposure. iS Clinical recommends continuing sun protection for at least a week after discontinuing use.

The primary difference is the concentration of retinol. The 0.3% version is a gentler formula ideal for beginners or those with sensitive skin, while the 1.0% version delivers a more potent dose suited to experienced retinol users with more resilient skin. Many people start with the 0.3% to build tolerance and then progress to the 1.0% for more intensive anti-ageing results once their skin has adapted.

Extremozyme® is iS Clinical's proprietary technology featuring Ectoin, a powerful stress-protection molecule found in organisms that thrive in extreme environments such as high-salt deserts and the Dead Sea. In skincare, it acts as a protective shield for the skin, offering anti-inflammatory and barrier-supportive benefits while helping to prevent transepidermal water loss. It works to defend the skin against environmental aggressors and oxidative stress during the retinol renewal process.

Yes. Retinol promotes cell turnover which helps to fade dark spots and uneven pigmentation over time. This formula also contains stabilised vitamin C for additional brightening support. Consistent use helps to diminish the appearance of post-inflammatory hyperpigmentation, sun spots, and general discolouration for a more uniform complexion.

It's best not to layer the Retinol+ Emulsion with strong exfoliants (such as AHAs, BHAs, or benzoyl peroxide) on the same evening unless directed by a skincare professional. However, it works beautifully alongside hydrating serums, barrier-repair products, and antioxidants. You can use vitamin C in your morning routine and the Retinol+ Emulsion in the evening for a complementary approach.

Most users begin to notice smoother skin texture and a more even tone within 4–6 weeks of consistent use. More significant improvements to fine lines, pigmentation, and overall skin clarity typically become visible at 8–12 weeks. With continued use, skin becomes progressively brighter, firmer, and more resilient over time.

The 0.3% concentration is specifically designed as an ideal entry point for those new to retinol or with sensitive skin. The encapsulated delivery system ensures retinol is released slowly and gently, minimising the risk of irritation. Many users with previously reactive skin report excellent tolerance when following the recommended gradual introduction schedule of every 3 days for the first 3 weeks.

This formula uses bio-identical lipid encapsulation to deliver retinol gradually into the skin, rather than releasing it all at once on the surface. This controlled, time-released approach significantly reduces the irritation, redness, and flaking commonly associated with retinol. It's further enhanced by a botanical booster triad of rice bran, vitamin E, and rosemary that increases retinol potency by over 30%, plus Bakuchiol for additional skin-refining benefits with higher tolerability.