Medik8 Exo-PDRN Prismatic+

It is the one with published data on exactly that: in Medik8's 4-week consumer study on 52 people who had received polynucleotide injectables within the previous week, 100% agreed it was the perfect post-procedure partner and 98% agreed results kept improving. Medik8 also left out the spicules many exosome serums use, because they can be harsh on post-procedure skin. We cannot rank every serum on the market, but for skin fresh from a clinic it is the one Becci recommends.

PDRN (polydeoxyribonucleotide) is a chain of DNA fragments, best known from polynucleotide injectables, used in skincare to support the skin's natural recovery. Most PDRN is extracted from salmon; Medik8's prismatic PDRN is vegan, certified by The Vegan Society, and engineered into a stable tetrahedral shape that the brand's in vitro study shows absorbing 2x better and penetrating around 60% deeper than salmon or rose PDRN.

Exosomes are tiny messenger vesicles that carry signals between cells. Medik8's triple exosome complex - up to 151 billion exosomes per bottle - is designed to support the skin's natural signalling, resilience and recovery and help strengthen the barrier. The formula is certified by The Vegan Society, so the exosomes are not animal-derived; the ingredient list shows Lactobacillus extracellular vesicles (from a probiotic ferment) alongside pomegranate and kelp extracts.

Absolutely - Medik8 calls them an ideal age-defying duo. Layer thinnest to thickest: Exo-PDRN Prismatic+ first, let it absorb, then Crystal Retinal, then moisturiser. Crystal Retinal targets every sign of ageing at night; Exo-PDRN supports long-term rejuvenation and recovery twice a day.

Medik8's own guidance: choose Liquid Peptides Advanced MP if your main goal is line-smoothing, as its Dual MiniProteins and peptide complex specifically target expression lines and build visible wrinkle reduction. Choose Exo-PDRN Prismatic+ if your skin needs comprehensive rejuvenation, recovery and glow. They complement each other, and if you use both, apply Exo-PDRN Prismatic+ first, then Liquid Peptides Advanced MP, morning and evening.

That is what Medik8 designed and tested it for - the consumer study was run on people who had had polynucleotide injectables within the previous week, and the formula has no spicules or exfoliants. Always follow your own practitioner's aftercare advice on when to restart active skincare after any procedure.

Yes to both. Medik8 pairs it with C-Tetra Advanced in the morning - apply Exo-PDRN Prismatic+ first, then the vitamin C, then sunscreen - and says it can be applied after exfoliating acids such as Press & Glow, ideally followed by a moisturiser to support the barrier.

Yes on every count, according to Medik8: it is designed to be gentle and suitable for sensitive skin, it is oil free so suits oily skin without shine, it contains hydrating and soothing ingredients for dry skin (add a moisturiser on top for comfort), and it has been tested to layer seamlessly under make-up.

It contains no vitamin A and no exfoliating acids, but Medik8 publishes no pregnancy or breastfeeding guidance for this product at all, and PDRN, exosomes and a growth-factor mini-protein are newer technologies without the long track record of simpler ingredients. Please discuss the full ingredient list with your midwife or GP before use.