iS Clinical Poly-Vitamin Serum

Poly-Vitamin Serum is an intensive revitalising treatment that combines 40% botanically derived hyaluronic acid with essential vitamins A, B3, B5, E, and glycolic acid from sugarcane. It deeply hydrates, boosts cellular metabolism, promotes gentle exfoliation, and helps restore skin that is dry, dull, ageing, or compromised. Think of it as a multivitamin for your skin — delivering everything your cells need to function at their best.

If your skin is dehydrated, dull, or showing visible signs of ageing, Poly-Vitamin Serum is one of the most comprehensive hydrating treatments available. With 40% hyaluronic acid for deep hydration, 5% niacinamide to support skin vitality, and 0.5% retinol to encourage cellular renewal, it goes far beyond basic hydration. It's trusted by dermatologists and skin therapists worldwide — including in oncology settings — for its ability to restore even the most compromised skin.

Best used in the evening after cleansing. Dispense 3–5 drops into clean hands and smooth over the face and neck. Allow it to absorb fully before applying moisturiser. It can be used morning and evening if tolerated, but evening use is recommended for optimal results due to the retinol content. Always follow with SPF during the day.

A temporary flushing or tingling sensation is completely normal and indicates that the active ingredients — particularly the niacinamide and glycolic acid — are stimulating microcirculation and encouraging gentle exfoliation. This typically subsides within a few minutes. If irritation persists, reduce frequency of use or consult your skincare professional.

This product is not recommended for those with rosacea. The formula contains ingredients that promote microcirculation within the skin, which may aggravate rosacea symptoms. If you have rosacea or redness-prone skin, consider iS Clinical Pro-Heal Serum Advance+ instead, which is specifically formulated to calm and soothe reactive skin.

Yes. Poly-Vitamin Serum is widely used in professional clinical settings for post-procedure recovery and compromised skin conditions. Its nutrient-rich, botanical formula is designed to support healing, restore hydration, and improve overall skin integrity. It is also used as part of iS Clinical's cancer care range for patients experiencing skin side effects from treatments. Always consult your skincare professional for personalised advice.

Yes. The combination of 0.5% retinol to promote collagen synthesis, 40% hyaluronic acid to plump and hydrate, and 4% glycolic acid to encourage cell turnover makes this serum highly effective at reducing the appearance of fine lines and improving skin texture. Consistent evening use delivers the best anti-ageing results over time.

While both serums offer hydration, they serve different purposes. Poly-Vitamin Serum is a rejuvenating vitamin treatment with retinol, niacinamide, and glycolic acid — ideal for ageing, dry, or compromised skin that needs active renewal. Hydra-Cool Serum is a lightweight, cooling hydrator with centella asiatica and hyaluronic acid — better suited for calming sensitive, inflamed, or post-procedure skin without active exfoliating ingredients.

This product contains retinol (vitamin A), which is generally advised against during pregnancy and breastfeeding. iS Clinical recommends consulting with your physician before use if you are pregnant, planning to become pregnant, or nursing. Your doctor can advise on whether this product is suitable for you during this time.