iS Clinical Pro-Heal Serum Advance+

Pro-Heal Serum Advance+ contains retinol, which is generally advised against during pregnancy and breastfeeding. iS Clinical recommends consulting with your physician before using this product if you are pregnant, planning to become pregnant, or nursing. Your healthcare provider can advise on the best skincare approach for your individual needs during this time.

Both sizes contain the exact same formula – the only difference is the volume. The 15ml is ideal for trying the serum for the first time or for travel, while the 30ml is the standard full-size bottle that offers better value for regular daily use. The product and packaging are identical in terms of quality and formulation.

Yes, Pro-Heal Serum Advance+ is widely recommended by dermatologists and skincare professionals for use following professional treatments such as chemical peels, laser therapy, and microneedling. Its soothing, anti-inflammatory properties help calm the skin during the recovery process whilst providing essential antioxidant protection. Always follow your practitioner's specific post-treatment guidance regarding when to reintroduce active products.

The 30ml bottle typically lasts around 2–3 months when used as directed (3–4 drops per application, once or twice daily). The serum is highly concentrated, so a little goes a long way. For those using it once daily, you can expect the bottle to last closer to 3 months. iS Clinical also offers a 15ml size for those wanting to try the serum before committing to the full size.

Yes, Pro-Heal Serum Advance+ layers well with most skincare actives. It pairs beautifully with hyaluronic acid serums for added hydration – many users apply it alongside iS Clinical Hydra-Cool Serum. It can also be used in the same routine as niacinamide and peptide products. However, if you are using additional exfoliating acids (such as glycolic or salicylic acid), introduce them gradually to avoid over-stimulating the skin. Always follow with sunscreen in the morning.

While both are premium vitamin C serums from iS Clinical, they target different concerns. Pro-Heal Serum Advance+ is formulated specifically for compromised, sensitive, and reactive skin, with a focus on calming inflammation and reducing redness. It contains olive leaf extract and zinc sulfate for soothing benefits. Super Serum Advance+ is more targeted towards anti-ageing and brightening with a broader combination of botanical actives. If your primary concern is sensitivity, redness, or blemish-prone skin, Pro-Heal is the ideal choice.

This serum is a multi-tasking treatment that addresses several skin concerns simultaneously. It helps calm visible redness and inflammation, improve the appearance of blemish-prone skin, brighten uneven skin tone and dark spots, reduce the appearance of fine lines and wrinkles, and protect against environmental damage. It is particularly well-suited for those dealing with rosacea-prone skin, acne, hyperpigmentation, and signs of ageing.

Pro-Heal Serum Advance+ is widely regarded as one of the best vitamin C serums for sensitive and reactive skin types. Unlike many vitamin C formulas that can cause irritation and stinging, this serum is specifically designed to calm and soothe the skin whilst delivering powerful antioxidant protection. The combination of L-ascorbic acid with olive leaf extract and zinc sulfate means you get all the brightening and protective benefits of vitamin C without the harshness often associated with high-potency formulas.

Pro-Heal Serum Advance+ is an excellent choice for blemish-prone and acne-prone skin. The formula's anti-inflammatory properties help reduce the redness and irritation associated with breakouts, while the retinol content supports healthy cell turnover to help prevent clogged pores. Arbutin works to fade post-breakout marks and hyperpigmentation, giving you a clearer, more even complexion over time. Many users with hormonal and cystic acne report significant improvements with consistent use.